Samantha Who?

Christina Applegate

Samantha Newly· 35 ep

Jennifer Esposito

Andrea Belladonna· 35 ep

Kevin Dunn

Howard· 35 ep

Melissa McCarthy

Dena· 35 ep

Tim Russ

Frank· 35 ep

Barry Watson

Todd· 35 ep

Jean Smart

Regina Newly· 35 ep

Rick Hoffman

Chase Chapman· 9 ep

Stephen Rannazzisi

Seth· 6 ep

Billy Zane

Winston Funk· 5 ep

Kiele Sanchez

Chloe· 4 ep

James Tupper

Owen· 4 ep

Joy Osmanski

Tracy· 4 ep

McKinley Freeman

Tony Dane· 4 ep

Eliza Coupe

Willow· 2 ep

Eddie Cibrian

Kevin· 2 ep

Dana Sorman

Jerri· 2 ep

Adam Devine

Tyler· 2 ep

Nakia Burrise

Kerry Hall· 1 ep

Timothy Olyphant

Winston Funk· 1 ep

Natasha Leggero

Woman Customer· 1 ep

Anthony Anderson

Rafael Grace· 1 ep

Mark Ballas

Mateo Romero· 1 ep

Tony Hale

Andy Adams· 1 ep

Teddy Sears

Brad· 1 ep

Rebecca Wisocky

Lindsey· 1 ep

Brett Rickaby

AA Leader· 1 ep

Beth Littleford

Audrey Rhodes· 1 ep

Ryan Carnes

Brent· 1 ep

Cybill Shepherd

Paula Drake· 1 ep

Mary-Kate Olsen

Natalie· 1 ep

James Patrick Stuart

Bill Jacobs· 1 ep

Andre Ware

Mac Fresh· 1 ep

Jerry O'Connell

Craig· 1 ep

Miranda May

13-Year-Old Dena· 1 ep

William Abadie

Rene· 1 ep

Jelynn Sophia

Angry Woman· 1 ep

Dan Thiel

Dave· 1 ep

Adam Jennings

Barista· 1 ep

Jill Talley

AA Female Leader· 1 ep

Frank Maharajh

Dr. Kegoshian· 1 ep

Jamison Haase

Vic· 1 ep

B.J. Clinkscales

Waiter· 1 ep

Jessica St. Clair

Valerie· 1 ep

Gerald Downey

Paul· 1 ep

Curt Cornelius

Trey· 1 ep

Amanda Young

Paul's Wife· 1 ep

Kara Taitz

Bridesmaid· 1 ep

Ryan Carlberg

Jason· 1 ep

Rand Holdren

Ryan· 1 ep

Sarah Spiegel

Young Woman· 1 ep

Todd Grinnell

Nathan· 1 ep

Johanna Braddy

Teenage Samantha· 1 ep

Jagger Chase

Kid· 1 ep

Kelsey Lee Smith

Young Samantha· 1 ep

Marilyn Sue Perry

Cashier· 1 ep

Arshad Aslam

Barista· 1 ep

Reggie Jordan

Flower Delivery Guy· 1 ep

Timon Kyle Durrett

Russ· 1 ep

Tanya Bond

Girl· 1 ep

Ossie Mair

Driver· 1 ep

Jaclyn Kerhulas

Sign Language Interpreter· 1 ep

Morgan Murphy

Woman Protestor· 1 ep

Jim Rash

Artist· 1 ep

Jonathan Schmock

Hipster· 1 ep

Brandon Ford Green

Guy· 1 ep

Ian Duncan

Cameron· 1 ep

Soledad Campos

Woman· 1 ep

Tony Winters

Man· 1 ep

Melody Butiu

Nurse· 1 ep

Brian Catalano

Orderly· 1 ep

Sarah Rafferty

Kayla Kaminski· 1 ep

Gregory Franklin

Announcer· 1 ep

Rachel Cannon

Carol· 1 ep

Phoebe Dorin

Older Woman· 1 ep

Brian D. Phelan

Cute Guy· 1 ep

William Borger

Crying Kid· 1 ep

Roxana Ortega

Allison· 1 ep

Steve Wilson

Foreman· 1 ep

Carla Greene

Waitress· 1 ep

Annette M. Lesure

Waitress· 1 ep

Sayeed Shahidi

Little Boy· 1 ep

Marsh Mokhtari

Mike· 1 ep

Joni Kempner

Cameron· 1 ep

Cooper Thornton

Instructor· 1 ep

David Douglas

Barista· 1 ep

Mary Alyce Kania

Waitress· 1 ep

Barry Finkel

Funeral Director· 1 ep

Laurie Okin

Mother· 1 ep

Stefan Marks

Detective Harp· 1 ep

Ty Barnett

Mugger· 1 ep

Karlton Johnson

Policeman· 1 ep

Tara Ochs

Waitress· 1 ep

Michael Crider

Roth· 1 ep

Ken Rudulph

Reporter· 1 ep

Brent Tarnol

Jason· 1 ep

John Taylor

Tommy Wylder· 1 ep

Greg Cipes

Street Musician· 1 ep

Terryn Westbrook

Female Fan #1· 1 ep

Kathryn Taylor Smith

Female Fan #2· 1 ep

Susie Geiser

Woman· 1 ep

Amanda Collier

13-Year-Old Samantha· 1 ep

Dondré Whitfield

Wes Green· 1 ep

Robin Gwynne

Wife· 1 ep

Christine Ebersole

Amy· 1 ep

Florence Henderson

Loretta· 1 ep

Nora Dunn

Cheryl· 1 ep

Hahn Cho

Doctor· 1 ep

Terrance Christopher Jones

Teacher· 1 ep

Abdoulaye N'Gom

Minister· 1 ep

Denise Gossett

Homeless Woman· 1 ep

Indira G. Wilson

Photographer· 1 ep

Charles C. Stevenson Jr.

Gentleman· 1 ep

Angie Harmon

Gigi· 1 ep

Bree Condon

Mickey· 1 ep

Jackie Johnson

Jackie Johnson· 1 ep

Shulie Cowen

Dolly· 1 ep

Greg Callahan

Fake Dad· 1 ep

David Trice

Baggage Service Rep· 1 ep

Anna Zielinski

Ticket Agent· 1 ep

Andre M. Johnson

Security Guard· 1 ep

J.P. Gillain

Philippe· 1 ep

Larry Reitzer

Duncan Weber· 1 ep

Tony Jones

Police Sergeant· 1 ep