One Fine Day

Michelle Pfeiffer

Melanie Parker

George Clooney

Jack Taylor

Mae Whitman

Maggie Taylor, Jack's daughter

Alex D. Linz

Sammy Parker, Melanie's son

Charles Durning

Lew, Jack's boss

Jon Robin Baitz

Mr. Yates, Jr.

Ellen Greene

Mrs. Elaine Lieberman

Amanda Peet

Celia

Joe Grifasi

Manny Feldstein

Pete Hamill

Frank Burroughs

Anna Maria Horsford

Evelyn

Gregory Jbara

Freddy

Sheila Kelley

Kristen, Jack's ex-wife

Bitty Schram

Marla

Barry Kivel

Mr. Yates, Sr.

Robert Klein

Dr. Martin

George Martin

Mr. Smith Leland

Michael Massee

Eddie Parker

Holland Taylor

Rita

Rachel York

Liza

Marianne Muellerleile

Ruta

Steven Jang

Vincent Wang

Samantha Cintrón

Rosa Lopez

Victor Truro

Sammy's Pediatrician

Ashley Greenfield

Jessica

Sidney Armus

Mayor Sidney Aikens

Hal Panchansky

Metro Reporter

Maggie Wagner

Daily News Reporter

Isabelle Ashland

Daily News Reporter

Jasmin Hartmann

Daily News Reporter

Larry Sherman

Daily News Visitor

Shaun Duke

Foreign Artist Guy

Thomas Schall

Gentleman

Michael Badalucco

Lt. Bonomo

Jeanie Van Dam

Old Woman

Kirstin Allen

Pregnant Saleslady

Michael Genet

Mayor Aikens' Press Secretary

Julia Ryder Perce

Lew's Secretary

P.J. Aliseo

Spiderman

Liam Ahern

The Incredible Hulk

José Rabelo

Museum Guard

Darla Hill

Oribe's Receptionist

Joe Avellar

Reporter

Jullie Chung

Reporter

Dale Kasman

Lady in the Police Station

Andrew Magarian

Bum in the Police Station

Katherine Argo

Passerby #1

Rob Buntzen

Passerby #2

Brian Cahill

Passerby #3

Fred Goehner

Davis

Kuniko Narai

Flower Shop Employee

Gideon Jacobs

Billy (uncredited)