Heart and Souls

Robert Downey Jr.

Thomas Reilly

Charles Grodin

Harrison Winslow

Alfre Woodard

Penny Washington

Kyra Sedgwick

Julia

Tom Sizemore

Milo Peck

David Paymer

Hal the Bus Driver

Elisabeth Shue

Anne

Bill Calvert

Frank Reilly

Lisa Lucas

Eva Reilly

Eric Lloyd

Thomas Reilly - Age 7

Shannon Orrock

Woman at Audition

Michael Zebulon

Singer at Audition

Chasiti Hampton

Shirley Washington - Age 7

Wanya Green

Diane Washington - Age 8

Janet MacLachlan

Agnes Miller

Javar David Levingston

Billy Washington - Age 4

Robert William Newhart

Bob Newhart

Sean O'Bryan

John McBride

Steven Clawson

Bartender

John Stuart Morris

Wanda

George Maguire

Music Director

Marc Shaiman

Piano Accompanist

Richard Portnow

Max Marco

Jacob Kenner

Duane Dortmueller - Age 10

Janette Caldwell

Woman in Cadillac

Janet Rotblatt

Mrs. Brodsky

Bill Capizzi

Race Track Ticket Clerk

Will Nye

Frank's Football Buddy

Eric Poppick

Mr. Polito

Susan Kellermann

Noelle

Robert Parnell

Mitchell

Ed Hooks

Jim

Michael Halton

Motorcycle Cop

Wren T. Brown

Sgt. Wm. Barclay

Richard Roat

Anne's Dad

Lorinne Vozoff

Anne's Mom

Bob Amaral

Duane Dortmueller

Luana Anders

Records Bureaucrat

John Goodwin

Security Guard

John Durbin

Stage Manager

B.B. King

Himself

Walter Riley King

B.B. King's Band

Melvin Jackson

B.B. King's Band

Leon Warren

B.B. King's Band

James Toney

B.B. King's Band

Michael Doster

B.B. King's Band

Calep Emphrey Jr.

B.B. King's Band

Tony Coleman

B.B. King's Band

Kymberly Newberry

Angela Barclay

Jamilah Adams Mapp

Samantha Barclay - Age 3

Tony Genaro

Man at Farmhouse

Melissa Biggs

Beatnik (uncredited)

Paul Moncrief

Concert Spectator (uncredited)

Kurtwood Smith

Patterson (uncredited)

Keaton Tyndall

Baby Thomas Reilly (uncredited)

Kylie Tyndall

Baby Thomas Reilly (uncredited)

Chloe Webb

Patient in Psychiatric Ward (uncredited)